rFactor 2 features mixed class road racing with ultra realistic dynamics, an immersive sound environment and stunning graphics, perfect for top-level esports and a rich single. It offers the latest in vehicle and race customization, great graphics, outstanding multiplayer and the height of racing realism. Any such selection may introduce statistical artefacts, and must always be described when reporting R factors. rFactor 2 is a realistic, easily extendable racing simulation from Studio 397.

However, occasionally reflections are omitted from the calculation, either because they are believed to result from a systematic experimental error or are recorded with an intensity small compared with background noise. rFactor 2 is a computer racing simulator created by the American independent software firm Image Space Incorporated and since 2016 developed by Studio 397. Because the pattern of liver injury can evolve over time, the time point at which liver chemistries are used to calculate the R Factor can alter the final result. The sum is usually computed over all reflections measured in the experiment. Calculating the R Factor is the first step in calculating the Roussel Uclaf Causality Assessment Method (RUCAM) when determining if liver injury is related to a specific drug.

The term R factor in crystallography is commonly taken to refer to the 'conventional' R factor